AustralieFrV1, Main, Exploration, bibRecord, 002683

Treatment with two different doses of sonidegib in patients with locally advanced or metastatic basal cell carcinoma (BOLT): a multicentre, randomised, double-blind phase 2 trial.

Identifieur interne : 002683 ( Main/Exploration ); précédent : 002682; suivant : 002684

Treatment with two different doses of sonidegib in patients with locally advanced or metastatic basal cell carcinoma (BOLT): a multicentre, randomised, double-blind phase 2 trial.

Auteurs : Michael R. Migden [États-Unis] ; Alexander Guminski [Australie] ; Ralf Gutzmer [Allemagne] ; Luc Dirix [Belgique] ; Karl D. Lewis [États-Unis] ; Patrick Combemale [France] ; Robert M. Herd [Royaume-Uni] ; Ragini Kudchadkar [États-Unis] ; Uwe Trefzer [Allemagne] ; Sven Gogov [Suisse] ; Celine Pallaud [Suisse] ; Tingting Yi [États-Unis] ; Manisha Mone [États-Unis] ; Martin Kaatz [Allemagne] ; Carmen Loquai [Allemagne] ; Alexander J. Stratigos [Grèce] ; Hans-Joachim Schulze [Allemagne] ; Ruth Plummer [Royaume-Uni] ; Anne Lynn S. Chang [États-Unis] ; Frank Cornélis [Belgique] ; John T. Lear [Royaume-Uni] ; Dalila Sellami [États-Unis] ; Reinhard Dummer [Suisse]

Source :

The Lancet. Oncology [ 1474-5488 ] ; 2015.

RBID : pubmed:25981810

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Carcinome basocellulaire (), Carcinome basocellulaire (anatomopathologie), Carcinome basocellulaire (radiothérapie), Carcinome basocellulaire (traitement médicamenteux), Dérivés du biphényle (administration et posologie), Dérivés du biphényle (effets indésirables), Estimation de Kaplan-Meier, Femelle, Humains, Mâle, Métastase tumorale, Méthode en double aveugle, Pyridines (administration et posologie), Pyridines (effets indésirables), Récidive tumorale locale (), Récidive tumorale locale (anatomopathologie), Récidive tumorale locale (radiothérapie), Récidive tumorale locale (traitement médicamenteux), Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Survie sans rechute, Tumeurs cutanées (), Tumeurs cutanées (anatomopathologie), Tumeurs cutanées (radiothérapie), Tumeurs cutanées (traitement médicamenteux).
MESH :
- administration et posologie : Dérivés du biphényle, Pyridines.
- anatomopathologie : Carcinome basocellulaire, Récidive tumorale locale, Tumeurs cutanées.
- effets indésirables : Dérivés du biphényle, Pyridines.
- radiothérapie : Carcinome basocellulaire, Récidive tumorale locale, Tumeurs cutanées.
- traitement médicamenteux : Carcinome basocellulaire, Récidive tumorale locale, Tumeurs cutanées.
- Adulte, Adulte d'âge moyen, Carcinome basocellulaire, Estimation de Kaplan-Meier, Femelle, Humains, Mâle, Métastase tumorale, Méthode en double aveugle, Récidive tumorale locale, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Survie sans rechute, Tumeurs cutanées.

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Biphenyl Compounds (administration & dosage), Biphenyl Compounds (adverse effects), Carcinoma, Basal Cell (drug therapy), Carcinoma, Basal Cell (pathology), Carcinoma, Basal Cell (radiotherapy), Carcinoma, Basal Cell (surgery), Disease-Free Survival, Double-Blind Method, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Neoplasm Metastasis, Neoplasm Recurrence, Local (drug therapy), Neoplasm Recurrence, Local (pathology), Neoplasm Recurrence, Local (radiotherapy), Neoplasm Recurrence, Local (surgery), Pyridines (administration & dosage), Pyridines (adverse effects), Skin Neoplasms (drug therapy), Skin Neoplasms (pathology), Skin Neoplasms (radiotherapy), Skin Neoplasms (surgery), Treatment Outcome.
MESH :
- chemical , administration & dosage : Biphenyl Compounds, Pyridines.
- chemical , adverse effects : Biphenyl Compounds, Pyridines.
- drug therapy : Carcinoma, Basal Cell, Neoplasm Recurrence, Local, Skin Neoplasms.
- pathology : Carcinoma, Basal Cell, Neoplasm Recurrence, Local, Skin Neoplasms.
- radiotherapy : Carcinoma, Basal Cell, Neoplasm Recurrence, Local, Skin Neoplasms.
- surgery : Carcinoma, Basal Cell, Neoplasm Recurrence, Local, Skin Neoplasms.
- Adult, Aged, Aged, 80 and over, Disease-Free Survival, Double-Blind Method, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Neoplasm Metastasis, Treatment Outcome.

Abstract

Patients with advanced basal cell carcinoma have limited treatment options. Hedgehog pathway signalling is aberrantly activated in around 95% of tumours. We assessed the antitumour activity of sonidegib, a Hedgehog signalling inhibitor, in patients with advanced basal cell carcinoma.

DOI: 10.1016/S1470-2045(15)70100-2
PubMed: 25981810

Affiliations:

Le document en format XML

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<author><name sortKey="Migden, Michael R" sort="Migden, Michael R" uniqKey="Migden M" first="Michael R" last="Migden">Michael R. Migden</name>
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<author><name sortKey="Combemale, Patrick" sort="Combemale, Patrick" uniqKey="Combemale P" first="Patrick" last="Combemale">Patrick Combemale</name>
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<author><name sortKey="Herd, Robert M" sort="Herd, Robert M" uniqKey="Herd R" first="Robert M" last="Herd">Robert M. Herd</name>
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<author><name sortKey="Kudchadkar, Ragini" sort="Kudchadkar, Ragini" uniqKey="Kudchadkar R" first="Ragini" last="Kudchadkar">Ragini Kudchadkar</name>
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<wicri:regionArea>Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, FL</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
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<author><name sortKey="Trefzer, Uwe" sort="Trefzer, Uwe" uniqKey="Trefzer U" first="Uwe" last="Trefzer">Uwe Trefzer</name>
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<author><name sortKey="Gogov, Sven" sort="Gogov, Sven" uniqKey="Gogov S" first="Sven" last="Gogov">Sven Gogov</name>
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<author><name sortKey="Pallaud, Celine" sort="Pallaud, Celine" uniqKey="Pallaud C" first="Celine" last="Pallaud">Celine Pallaud</name>
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<author><name sortKey="Yi, Tingting" sort="Yi, Tingting" uniqKey="Yi T" first="Tingting" last="Yi">Tingting Yi</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Biometrics and Data Management, Oncology Business Unit, Novartis Pharmaceuticals Corporation, East Hanover, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mone, Manisha" sort="Mone, Manisha" uniqKey="Mone M" first="Manisha" last="Mone">Manisha Mone</name>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Kaatz, Martin" sort="Kaatz, Martin" uniqKey="Kaatz M" first="Martin" last="Kaatz">Martin Kaatz</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Dermatology and Allergology, University Hospital Jena, Jena, Germany; SRH Wald-Klinikum Gera, Gera</wicri:regionArea>
<wicri:noRegion>Gera</wicri:noRegion>
<wicri:noRegion>Gera</wicri:noRegion>
<wicri:noRegion>Gera</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Loquai, Carmen" sort="Loquai, Carmen" uniqKey="Loquai C" first="Carmen" last="Loquai">Carmen Loquai</name>
<affiliation wicri:level="3"><nlm:affiliation>Deparment of Dermatology, University Medical Center Mainz, Mainz, Germany.</nlm:affiliation>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Stratigos, Alexander J" sort="Stratigos, Alexander J" uniqKey="Stratigos A" first="Alexander J" last="Stratigos">Alexander J. Stratigos</name>
<affiliation wicri:level="3"><nlm:affiliation>Deparment of Dermatology, Andreas Sygros Hospital, University of Athens, Athens, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
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<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schulze, Hans Joachim" sort="Schulze, Hans Joachim" uniqKey="Schulze H" first="Hans-Joachim" last="Schulze">Hans-Joachim Schulze</name>
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<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Münster</region>
<settlement type="city">Münster</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Plummer, Ruth" sort="Plummer, Ruth" uniqKey="Plummer R" first="Ruth" last="Plummer">Ruth Plummer</name>
<affiliation wicri:level="1"><nlm:affiliation>Northern Centre for Cancer Care, Freeman Hospital, Newcastle upon Tyne, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
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</affiliation>
</author>
<author><name sortKey="Chang, Anne Lynn S" sort="Chang, Anne Lynn S" uniqKey="Chang A" first="Anne Lynn S" last="Chang">Anne Lynn S. Chang</name>
<affiliation wicri:level="2"><nlm:affiliation>Deparment of Dermatology, Stanford University School of Medicine, Redwood City, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Deparment of Dermatology, Stanford University School of Medicine, Redwood City, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cornelis, Frank" sort="Cornelis, Frank" uniqKey="Cornelis F" first="Frank" last="Cornélis">Frank Cornélis</name>
<affiliation wicri:level="3"><nlm:affiliation>Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels</wicri:regionArea>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lear, John T" sort="Lear, John T" uniqKey="Lear J" first="John T" last="Lear">John T. Lear</name>
<affiliation wicri:level="4"><nlm:affiliation>Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Manchester Academic Health Science Centre, University of Manchester, Manchester</wicri:regionArea>
<placeName><settlement type="city">Manchester</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Manchester</region>
<settlement type="city">Manchester</settlement>
</placeName>
<orgName type="university">Université de Manchester</orgName>
</affiliation>
</author>
<author><name sortKey="Sellami, Dalila" sort="Sellami, Dalila" uniqKey="Sellami D" first="Dalila" last="Sellami">Dalila Sellami</name>
<affiliation wicri:level="2"><nlm:affiliation>Oncology Global Development, Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Oncology Global Development, Novartis Pharmaceuticals Corporation, East Hanover, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dummer, Reinhard" sort="Dummer, Reinhard" uniqKey="Dummer R" first="Reinhard" last="Dummer">Reinhard Dummer</name>
<affiliation wicri:level="3"><nlm:affiliation>Universitätsspital Zürich-Skin Cancer Center University Hospital, Zürich, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Universitätsspital Zürich-Skin Cancer Center University Hospital, Zürich</wicri:regionArea>
<placeName><settlement type="city">Zurich</settlement>
<region nuts="3" type="region">Canton de Zurich</region>
</placeName>
</affiliation>
</author>
</titleStmt>
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<date when="2015">2015</date>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Treatment with two different doses of sonidegib in patients with locally advanced or metastatic basal cell carcinoma (BOLT): a multicentre, randomised, double-blind phase 2 trial.</title>
<author><name sortKey="Migden, Michael R" sort="Migden, Michael R" uniqKey="Migden M" first="Michael R" last="Migden">Michael R. Migden</name>
<affiliation wicri:level="2"><nlm:affiliation>Mohs Surgery Center, Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: mrmigden@mdanderson.org.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mohs Surgery Center, Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guminski, Alexander" sort="Guminski, Alexander" uniqKey="Guminski A" first="Alexander" last="Guminski">Alexander Guminski</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Royal North Shore Hospital, St Leonards, NSW, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Medical Oncology, Royal North Shore Hospital, St Leonards, NSW</wicri:regionArea>
<wicri:noRegion>NSW</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gutzmer, Ralf" sort="Gutzmer, Ralf" uniqKey="Gutzmer R" first="Ralf" last="Gutzmer">Ralf Gutzmer</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology and Allergy, Medizinische Hochschule Hannover, Hannover, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Dermatology and Allergy, Medizinische Hochschule Hannover, Hannover</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dirix, Luc" sort="Dirix, Luc" uniqKey="Dirix L" first="Luc" last="Dirix">Luc Dirix</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Sint-Augustinus Ziekenhuis, Antwerp, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Medical Oncology, Sint-Augustinus Ziekenhuis, Antwerp</wicri:regionArea>
<wicri:noRegion>Antwerp</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lewis, Karl D" sort="Lewis, Karl D" uniqKey="Lewis K" first="Karl D" last="Lewis">Karl D. Lewis</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Medical Oncology, University of Colorado School of Medicine, Aurora, CO, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Medical Oncology, University of Colorado School of Medicine, Aurora, CO</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Combemale, Patrick" sort="Combemale, Patrick" uniqKey="Combemale P" first="Patrick" last="Combemale">Patrick Combemale</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Onco-Dermatology, Anticancer Institute, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Onco-Dermatology, Anticancer Institute, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Herd, Robert M" sort="Herd, Robert M" uniqKey="Herd R" first="Robert M" last="Herd">Robert M. Herd</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Glasgow Royal Infirmary, Glasgow, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Dermatology, Glasgow Royal Infirmary, Glasgow</wicri:regionArea>
<wicri:noRegion>Glasgow</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kudchadkar, Ragini" sort="Kudchadkar, Ragini" uniqKey="Kudchadkar R" first="Ragini" last="Kudchadkar">Ragini Kudchadkar</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, FL, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, FL</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Trefzer, Uwe" sort="Trefzer, Uwe" uniqKey="Trefzer U" first="Uwe" last="Trefzer">Uwe Trefzer</name>
<affiliation wicri:level="3"><nlm:affiliation>Dermatologikum Berlin, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dermatologikum Berlin, Berlin</wicri:regionArea>
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<series><title level="j">The Lancet. Oncology</title>
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<front><div type="abstract" xml:lang="en">Patients with advanced basal cell carcinoma have limited treatment options. Hedgehog pathway signalling is aberrantly activated in around 95% of tumours. We assessed the antitumour activity of sonidegib, a Hedgehog signalling inhibitor, in patients with advanced basal cell carcinoma.</div>
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Serveur d'exploration sur les relations entre la France et l'Australie

Treatment with two different doses of sonidegib in patients with locally advanced or metastatic basal cell carcinoma (BOLT): a multicentre, randomised, double-blind phase 2 trial.

Treatment with two different doses of sonidegib in patients with locally advanced or metastatic basal cell carcinoma (BOLT): a multicentre, randomised, double-blind phase 2 trial.

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